Ernest Rudak, writing at Just Text:

If you are a VoiceOver user and wondering if Unread is accessible, I have good news. The app is more than just accessible; it uses standard layouts, and all buttons and menus are clearly labeled. Unread is not only a pleasure to use from a visual perspective but also from a VoiceOver perspective. The Mac version is built with native technologies, specifically AppKit. What this means for you as a VoiceOver user is that the app behaves as it should, and you will not encounter cumbersome corners in the app that feel unfamiliar or strange.

Ernest’s review describes Unread in detail with a focus on its accessibility via VoiceOver.